Sleepless Nights

  • Sleeping five hours or less increases risk of chronic illnesses, study warns

    Original Article | By Judy Packer-Tursman

    Getting a good night's sleep of more than five hours can help older people avoid developing multiple chronic illnesses, a new study suggests. Photo by Wokandapix/Pixabay

    Getting a good night’s sleep of more than five hours can help older people avoid developing multiple chronic illnesses, a new study suggests. Photo by Wokandapix/Pixabay

    Oct. 18 (UPI) — Older people who get five hours of sleep a night or less may face a far greater risk of developing two or more chronic illnesses, such as heart disease, cancer or diabetes, compared to people who sleep longer, a new study suggests.

    The research, published Tuesday in the journal PLOS Medicine, tracked the impact of sleep duration on the health of more than 7,000 men and women at the ages of 50, 60 and 70.

    This was done via a 25-year follow up of participants in the Whitehall II cohort study involving members of the British civil service.

    The British and French researchers, led by University College London, found that sleeping for five hours or less at the ages of 50, 60, and 70 was linked to a 30% to 40% increased risk of developing multiple chronic diseases versus people who slept for up to seven hours.

    The investigators also examined the relationship between each participant’s length of nightly sleep and mortality. They found that nightly sleep that lasted five hours or less at age 50 was associated with a 25% increased risk of death over the 25 years of follow-up.

    This is primarily because short sleep duration increases the risk of chronic illness that in turn increases the risk of death, the release said.

    The scientists also analyzed whether sleeping for nine hours or more affected health outcomes, but they found no clear link between this sleep duration and developing chronic diseases for healthy people at age 50.

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    However, for those individuals already diagnosed with a chronic condition, such long sleep was associated with roughly a 35% increased risk of developing another illness, possibly due to underlying health conditions affecting sleep, they said.

    “As people get older, their sleep habits and sleep structure change. However, it is recommended to sleep for seven to eight hours a night — as sleep durations above or below this have previously been associated with individual chronic diseases,” Séverine Sabia, the study’s lead author said in the release.

    A researcher/epidemiologist at University College London’s Institute of Epidemiology & Health and at Inserm, Université Paris Cité, Sabia advised having good sleep hygiene, such as ensuring the bedroom is quiet, dark and a comfortable temperature before going to bed.

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    She also suggested avoiding large meals before bedtime.

    The study used self-reported data on sleep, which the researchers noted is likely to be subject to reporting bias.

    Sponsors of the research included the National Institute on Aging, a part of the National Institutes of Health, the U.K. Medical Research Council and the British Heart Foundation.

  • Body Clock Off-Schedule? Sleepless Nights?Prebiotics May Help

    Original Article Posted by Sleep Review Staff | Sep 16, 2021 | Jet Lag Disorder

    Whether it’s from jetting across time zones, pulling all-nighters at school or working the overnight shift, chronically disrupting our circadian rhythm—or internal biological clocks—can take a measurable toll on everything from sleep, mood and metabolism to risk of certain diseases, mounting research shows.

    But a new University of Colorado Boulder study funded by the U.S. Navy suggests simple dietary compounds known as prebiotics, which serve as food for beneficial gut bacteria, could play an important role in helping us bounce back faster.

    “This work suggests that by promoting and stabilizing the good bacteria in the gut and the metabolites they release, we may be able to make our bodies more resilient to circadian disruption,” senior author Monika Fleshner, a professor of integrative physiology, said in a statement.

    Woman Suffering from A Sleepless Night

    The animal study, published in the journal Brain, Behavior and Immunity, is the latest to suggest that prebiotics—not to be confused with probiotics found in fermented foods like yogurt and sauerkraut—can influence not only the gut, but also the brain and behavior.

    Naturally abundant in many fibrous foods—including leeks, artichokes and onions—and in breast milk, these indigestible carbohydrates pass through the small intestine and linger in the gut, serving as nourishment for the trillions of bacteria residing there.

    The authors’ previous studies showed that rats raised on prebiotic-infused chow slept better and were more resilient to some of the physical effects of acute stress.

    For the new study, part of a multi-university project funded by the Office of Naval Research, the researchers sought to learn if prebiotics could also promote resilience to body-clock disruptions from things like jet lag, irregular work schedules or lack of natural daytime light—a reality many military personnel live with.

    “They are traveling all over the world and frequently changing time zones. For submariners, who can be underwater for months, circadian disruption can be a real challenge,” said lead author Robert Thompson, a postdoctoral researcher in the Fleshner lab. “The goal of this project is to find ways to mitigate those effects.”

    How a healthy gut may prevent jet lag

    The researchers raised rats either on regular food or chow enriched with two prebiotics: galactooligosaccharides and polydextrose.

    They then manipulated the rats’ light-dark cycle weekly for eight weeks—the equivalent of traveling to a time zone 12 hours ahead every week for two months.

    Rats that ate prebiotics more quickly realigned their sleep-wake cycles and core body temperature (which can also be thrown off when internal clocks are off) and resisted the alterations in gut flora that often come with stress.

    “This is one of the first studies to connect consuming prebiotics to specific bacterial changes that not only affect sleep but also the body’s response to circadian rhythm disruption,” said Thompson.

    The study also takes a critical step forward in answering the question: How can simply ingesting a starch impact how we sleep and feel?

    The researchers found that those on the prebiotic diet hosted an abundance of several health-promoting microbes, including Ruminiclostridium 5 (shown in other studies to reduce fragmented sleep) and Parabacteroides distasonis.

    They also had a substantially different “metabolome,” the collection of metabolic byproducts churned out by bacteria in the gut.

    Put simply: The animals that ingested the prebiotics hosted more good bacteria, which in turn produced metabolites that protected them from something akin to jet lag.

    Are supplements worthwhile?

    Clinical trials are now underway at CU Boulder to determine if prebiotics could have similar effects on humans.

    The research could lead to customized prebiotic mixtures designed for individuals whose careers or lifestyles expose them to frequent circadian disruption.

    In the meantime, could simply loading up on legumes and other foods naturally rich in the compounds help keep your body clock running on time? It’s not impossible but unlikely, they say—noting that the rats were fed what, in human terms, would be excessive amounts of prebiotics.

    Why not just ingest the beneficial bacteria directly, via probiotic-rich foods like yogurt?

    That could also help, but prebiotics may have an advantage over probiotics in that they support the friendly bacteria one already has, rather than introducing a new species that may or may not take hold.

    What about prebiotic dietary supplements?

    “If you are happy and healthy and in balance, you do not need to go ingest a bunch of stuff with a prebiotic in it,” said Fleshner. “But if you know you are going to come into a challenge, you could take a look at some of the prebiotics that are available. Just realize that they are not customized yet, so it might work for you but it won’t work for your neighbor.”